… Neural tube closure is critical for the formation of the human brain and spinal cord.
Broader, more all-inclusive perspectives are emerging to identify the genetic determinants
of human NTDs. … Neural tube defects (NTDs) refer to a group of often severe congenital
malformations of the central nervous system that arise from a failure in neural tube closure
in the first month of human embryonic development. This failure can occur during the
processes of primary or secondary neurulation or postneurulation skeletogenesis. With a …